Evidence

Alerts

The latest important research summarised

Short summaries of the latest health research presented in plain English to promote use of research by all members of society.

Alert

Whole-body MRI is effective for identifying metastatic disease in colorectal cancer patients

Initial investigation which includes whole-body magnetic resonance imaging (MRI) is as good as standard pathways for detecting metastatic disease in adults with newly diagnosed colorectal cancer. This NIHR-funded study also found that whole-body MRI reduces the number of investigations needed, the length of the staging process, and costs less than standard pathways. The treatment options ...

Alert

Whole-body MRI scans are as accurate as standard imaging pathways for lung cancer staging

Using whole-body magnetic resonance imaging (MRI) in the initial investigation pathway is as good as standard pathways for detecting metastatic disease in adults with non-small-cell lung cancer. This NIHR-funded study also found that WB-MRI used for diagnosis and staging is quicker, cheaper and requires fewer other investigations than standard pathways. Although patients reported that having ...

Alert

Mixed evidence shows some impact of mass media campaigns promoting tobacco control, physical activity and sexual health

Mass media campaigns have demonstrated effectiveness for promoting tobacco control, physical activity and sexual health. Most of the evidence relates to improving awareness of health risks or the availability of services. However, for those aimed at the risks associated with sedentary lifestyles, smoking or sexual behaviours, there are signs that the campaigns also achieved positive ...

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Pulmonary rehabilitation may modestly improve anxiety and depression in adults with chronic obstructive pulmonary disease

Pulmonary rehabilitation for chronic obstructive pulmonary disease (COPD) improves psychological symptoms modestly, compared with no intervention. Depression improves by about 2.5 points, and anxiety by 2.2 points on the Hospital Anxiety and Depression Scale (range 0 to 21). This review of 10 trials is the first to show that pulmonary rehabilitation – already known to ...

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Insights into the transfer between children’s and adults’ services for young people with selected long-term conditions

How young people with type 1 diabetes, autistic spectrum disorder and cerebral palsy experience the transition to adult services depends on their condition and locality. Adult and children’s services need to work together to ensure they are offering young people the sources of support and resilience they need. This NIHR-funded study found that children with ...

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Routine use of progesterone does not prevent miscarriage

Progesterone did not affect the chance of live birth among women presenting with vaginal bleeding in the first 12 weeks of pregnancy. Live birth rates were 72% with placebo and 75% with progesterone, which is not a clinically or statistically important difference. Progesterone has been prescribed for threatened miscarriage in some centres since the 1950s, ...

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Transvaginal ultrasound and MRI achieve similar accuracy for diagnosing lower bowel endometriosis

Transvaginal ultrasound and magnetic resonance imaging (MRI) scans are both accurate ways to diagnose the most severe form of deep endometriosis affecting the bowel. By using both transvaginal ultrasound and MRI, the chance of non-invasively and accurately diagnosing endometriosis of the lower bowel rises to nearly 100%. This review and meta-analysis looked at eight studies ...

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Levetiracetam is a useful alternative to phenytoin in stopping prolonged epileptic seizures in children

Levetiracetam is as effective as phenytoin at stopping prolonged epileptic seizures in children. In this trial, levetiracetam stopped 70% of children convulsing compared with 64% for phenytoin within 35 to 45 minutes. Adverse events were similar. This combined with the fact levetiracetam may be easier to administer safely make it an important option. Most epileptic ...

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National quality improvement programmes need time and resources to have an impact

A large trial assessing the effectiveness of a UK-wide quality improvement programme did not show any difference in patient outcomes. However, the likely reasons for this were carefully investigated and provide some useful insights on implementation. Several (37) quality improvement components were included in the ambitious package designed to reduce variation in care and improve ...

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Meaningful increases in physical activity levels after cancer can be sustained for three months or more

People who have had cancer, who are able to keep mobile, can benefit from interventions aimed at increasing physical activity. Being active regularly is already known to improve health and may also reduce the risk of cancer returning and improve life expectancy. This NIHR-funded review looked at what kinds of exercise interventions can lead to ...

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