Evidence
Alert

Aspirin did not prevent deaths or disability in healthy older adults

In the ASPREE trial, older adults with no apparent cardiovascular disease who took daily aspirin saw no benefit in terms of reducing the chance of dying or having dementia or disability. Instead, it slightly increased their mortality and bleeding risk - aspirin was associated with an excess of 1.6 deaths per 1,000 people per year. ...

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The benefits and harms of aspirin for people with type 2 diabetes are finely balanced

Daily aspirin reduced the risk of serious vascular events among people with diabetes, while increasing the risk of major bleeding to a similar extent. Aspirin prevented one person in every 100 from having a heart attack or stroke over seven years, but an additional person per 100 experienced a major bleed. The ASCEND study is ...

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Fish oil supplements do not reduce cardiovascular deaths in people with diabetes without existing vascular disease

Omega-3 fatty acid supplements make no difference to cardiovascular outcomes in people with diabetes but without established cardiovascular disease. Serious vascular events like heart attack, stroke or deaths from these occurred in about 10% of people regardless of whether they took daily omega-3 or placebo capsules for seven years. The ASCEND study is a large UK ...

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Routine use of a mechanical compression device is no better than manual chest compression in cardiac arrest

Compared with manual compression, mechanical chest compression does not improve survival rates after cardiac arrest. However, in situations where manual compression may be difficult, such as in a moving ambulance, mechanical compression may still be an option. Each minute that a person waits for treatment after a cardiac arrest can make a difference of up ...

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Telemedicine programme can prolong life for heart failure patients

A comprehensive programme of daily telemedicine monitoring and 24-hour access to a physician-led hotline can reduce the number of deaths and the time spent in hospital, among patients with heart failure. A year-long study of 1,571 patients who had been admitted to hospital with heart failure within the past 12 months found that those assigned ...

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Abdominal aortic aneurysm screening for women is unlikely to be a fair use of NHS resources

Nearly 4,000 women would need screening to prevent one death, and a third of aneurysms detected wouldn’t have influenced the individual woman's health or lifespan. Aneurysm rupture is a life-threatening emergency with low survival. Men are known to be at higher risk of an aneurysm and are offered screening at age 65 to allow early ...

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Omega-3 supplements do not prevent heart disease, stroke or death

Omega-3 fatty acid supplements from fish oils or plants have little or no effect on the risk of heart disease, stroke or overall death rates. This finding contradicts a widespread belief that omega-3 supplements are protective. Previous evidence in favour of omega-3 supplements is mainly derived from trials at high risk of bias. The better ...

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Fewer wound hernias occur if mesh is used to reinforce abdominal aortic aneurysm surgery

Mesh reinforcement may result in patients developing fewer hernias at the incision site after aortic aneurysm surgery. This type of hernia is a common complication of midline (vertical) incisions and can cause pain and restrict everyday activities. Although using mesh was linked with fewer incisional hernias, this systematic review could not determine with any certainty ...

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Reminders help GPs to find and manage inherited cholesterol disorders

GPs and practice nurses assess more adults with inherited raised cholesterol (familial hypercholesterolaemia) when prompted by reminders. More patients have repeat cholesterol tests and assessments for heart disease, in line with NICE guidelines. This NIHR-funded study used electronic health records from six GP practices to identify patients with total cholesterol greater than 7.5mmol/l. Reminder messages ...

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People take prescribed statins more reliably after discussing their advantages and disadvantages

Patients want to know more about how statins work, the reasons for prescribing them and their possible side effects. Statins lower cholesterol and reduce the risk of recurrent stroke or heart attack. They also help prevent cardiovascular disease developing in people at high risk. At a population, level statins reduce the overall incidence of cardiovascular ...

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