Evidence
Themed Review

Forward Thinking - Support for people with severe mental illness

Severe mental illness (SMI) affects somewhere between one in one hundred and one in two hundred adults. People with severe mental illness, like schizophrenia, psychosis or bipolar disorder, often experience poorer health and, as a result, die sooner than others. Psychotic illnesses can have a profound effect on people and their families, and appropriate and ...

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Hypertonic saline as effective as normal saline for trauma patients

Solutions more concentrated than normal, such as hypertonic saline, are as good as those more usually given to trauma patients with severe blood loss. Survival to hospital discharge was the same in patients treated before arrival at the hospital with either type of fluid. There are around 20,000 cases of major trauma per year in ...

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Imaging is the only way to diagnose blood clots in pregnancy

No blood test can accurately tell if a pregnant or recently pregnant woman has a blood clot. All pregnant women with a suspected clot should continue to have imaging investigations as per current UK guidelines. This NIHR-funded study recruited 328 pregnant or postpartum women with a suspected blood clot in the lung (pulmonary embolism) or ...

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Pulmonary rehabilitation improves exercise tolerance in pulmonary fibrosis

People with idiopathic pulmonary fibrosis who received pulmonary rehabilitation could walk 44 metres further in six minutes than those who did no exercise. Quality of life also improved. Pulmonary fibrosis is a rare condition where scar tissue builds up in the lungs making them stiff and causing breathing difficulty. The term idiopathic means there is ...

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Statins are of no benefit in acute respiratory distress syndrome

Giving statins to patients with acute respiratory distress syndrome made no difference to the number of days they spent on a ventilator. It also had no effect on mortality or the length of time spent in intensive care or in hospital compared with placebo. In acute respiratory distress syndrome, the lungs become severely inflamed, fill ...

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Short-duration dual antiplatelet treatment is possible for older people receiving drug-coated stents

Drug-eluting stents are more effective than bare-metal stents for preventing repeat procedures to open narrowed heart arteries in older adults with coronary heart disease. In this trial both types of stents were used alongside short courses of dual antiplatelet medication, outcomes for those receiving drug-eluting stents were improved with no difference in bleeding complications or ...

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Mat Pilates probably improves balance and strength in older adults

Mat Pilates appears to improve muscle strength, flexibility, balance and cardiovascular fitness in older people compared to no exercise. There are limitations to the reliability of the evidence, but the consistent effect across all the aspects of fitness suggests this is probably a useful option for the increasing number of older people who wish to ...

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Waiting at home after inducing labour mechanically may be an option for low-risk women

Maternal or fetal complications, following the insertion of a balloon catheter to induce labour, are rare. Pain or discomfort was most common affecting around 1 in 400 women. Balloon displacement, bleeding or abnormal fetal heart rate affected less than 1 in 1,000. The catheter is a device inserted through the cervix, where inflated balloons on ...

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Inhaled anaesthesia with anti-sickness medication in children has the same risk of vomiting as intravenous anaesthesia

Post-operative vomiting is common in children. One strategy is to use an intravenous anaesthetic, which is known to cause lower rates of sickness than inhaled anaesthetics. There are disadvantages to this though, such as the need for injections before a child is asleep, slowing of the heart and difficulty in monitoring depth of the anaesthetic. ...

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Diet and exercise programmes can prevent diabetes in high-risk individuals

Lifestyle changes can reduce the risk of diabetes by about 40% and overall prevents about four high-risk individuals in 100 developing type 2 diabetes each year. The risk remained low for an average of about seven years after the intervention, but effects did decline over time. Medications including the weight-loss drug orlistat and diabetes drug ...

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