Evidence
Alert

Placental growth factor testing can speed up diagnosis of pre-eclampsia

Measuring the level of placental growth factor (PlGF) in women with suspected pre-eclampsia helps to reduce the time to diagnose pre-eclampsia from 4 days to 2 days. PlGF testing is also associated with fewer adverse outcomes for mothers. In this NIHR-funded trial, the test results were used alongside the NICE clinical management algorithm to help ...

Alert

Meaningful increases in physical activity levels after cancer can be sustained for three months or more

People who have had cancer, who are able to keep mobile, can benefit from interventions aimed at increasing physical activity. Being active regularly is already known to improve health and may also reduce the risk of cancer returning and improve life expectancy. This NIHR-funded review looked at what kinds of exercise interventions can lead to ...

Alert

National quality improvement programmes need time and resources to have an impact

A large trial assessing the effectiveness of a UK-wide quality improvement programme did not show any difference in patient outcomes. However, the likely reasons for this were carefully investigated and provide some useful insights on implementation. Several (37) quality improvement components were included in the ambitious package designed to reduce variation in care and improve ...

Themed Review

Moving Matters - Interventions To Increase Physical Activity

The NIHR physical activity evidence review will be an invaluable tool to anyone working in practice or policy. Evidence should be one of the key building blocks for any decisions. It helps decision makers determine what works and what doesn’t, what should be commissioned and prioritised, and (equally important) what should be stopped. The beauty ...

Alert

Using both nicotine patches and gum together improves the chances of quitting smoking

Using a nicotine patch together with a fast-acting type of nicotine replacement therapy (NRT) such as gum or lozenges improves smoking cessation rates compared to using only a single type of NRT. Higher-dose nicotine patches are also more effective than lower dose ones, this NIHR-funded review suggests. A previous Cochrane systematic review found that NRT ...

Alert

Telephone or internet delivered talking therapy can alleviate irritable bowel symptoms

People with irritable bowel syndrome may find cognitive behavioural therapy (a talking therapy) delivered via telephone or internet improves their symptoms. Compared with usual care alone, both interventions were shown to be more effective, with telephone delivery resulting in greater symptom reduction and web-based therapy being more cost-effective. Irritable bowel symptoms can persist long-term and ...

Alert

Antiretroviral treatment can reduce the risk of HIV transmission between male partners to ‘zero’

The risk of transmission of HIV between gay couples when the HIV-positive partner is taking antiretroviral treatment that successfully suppresses the viral load is ‘effectively zero.’ A study of men from 14 European countries, including the UK, found no cases of transmission of HIV from an HIV-positive partner taking antiretroviral therapy to an HIV-negative partner, ...

Alert

New insights into how fatigue affects the lives of people on dialysis

Feelings of profound and relentless exhaustion while undergoing haemodialysis impact on patients’ ability to lead a normal life. This overwhelming fatigue is different from the immediate symptoms of post-dialysis fatigue observable in a clinical setting and can pervade all aspects of a patient’s life. This review of 65 international studies, including 1,713 participants, found that ...

Alert

Antimicrobial central venous catheters do not reduce infections in pre-term babies

Central venous catheters (CVCs) impregnated with antimicrobial agents are no better than standard CVCs for avoiding bloodstream infection in pre-term babies. This NIHR-funded trial compared peripherally inserted CVCs that had been impregnated with a combination of the antifungal miconazole and the broad-spectrum antibiotic rifampicin, against standard non-antimicrobial-impregnated CVCs for preterm babies in intensive care. Rates ...

Alert

Providing pressurised air through a mask may improve outcomes for people with deteriorating heart failure

Non-invasive positive pressure ventilation may help people with rapidly deteriorating heart failure who become short of breath due to fluid build-up in the lungs. For people not requiring immediate mechanical ventilation using an endotracheal tube, this approach may reduce the risk of death in hospital and the need for intubation. This review evaluated 24 trials ...

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