Evidence
Alert

Teenagers' use of antidepressants is rising with variations across regions and ethnic groups

The number of 12-to-17 year olds prescribed antidepressants in England more than doubled between 2005 and 2017. This is one of the striking changes seen in a new study into the use of antidepressants by children and young people. It also found that antidepressant prescriptions for 5-to-11 year olds decreased between 1999 and 2017. Antidepressants ...

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Women with cancer of the stomach or oesophagus are more likely to survive than men, but they have worse side effects from chemotherapy

Women treated for cancer of the stomach or oesophagus (the muscular tube which moves food from mouth to stomach) may survive longer than men. An analysis of over 3000 patients with these cancers also found that women experienced more nausea, vomiting, and diarrhoea during therapy. Cancer-related survival was the same for older (70 or over) ...

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First-line chemotherapy for ovarian cancer given once every three weeks may preserve quality of life

Women with a new diagnosis of ovarian cancer receiving weekly chemotherapy may have reduced quality of life compared to those receiving treatment every three weeks because the more frequent treatment may cause long-lasting nerve damage. Ovarian cancer is usually treated every three weeks with chemotherapy containing the medicines carboplatin and paclitaxel. A study in Japan ...

Collection

Diabetes

The impact of diabetes and the challenges it presents individual patients, their families and health services is a major issue of interest and concern. At present an estimated 3.5 million people in the UK have been diagnosed with diabetes but it is predicted that up to a further 549,00 people have diabetes that is yet ...

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Missed miscarriage should be treated with mifepristone plus misoprostol rather than misoprostol alone

A combination of two drugs – mifepristone and misoprostol – was more effective than mifepristone alone for treating missed miscarriage. A large, multi-centre trial found that women given the combination were more likely to have completed their miscarriage within a week, and less likely to need follow-up surgery. During a miscarriage of pregnancy, the baby ...

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Ongoing pain after knee replacement: people need support and encouragement to seek help

People with ongoing pain after knee replacement surgery may experience a sense of futility and believe nothing more can be done. A new study found that that one in five people report ongoing pain after knee replacement surgery, but many do not seek help in dealing with their pain. The researchers say that improvements in ...

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Womb cancer could be detected early with an inexpensive new blood test

A simple, low-cost blood test offers great potential as a tool for diagnosing womb cancer, and for screening high-risk women. The test gives almost instant results and in a new study, it picked up changes in the womb that could lead to cancer (pre-cancerous growths). In the UK, womb cancer is the fourth most common ...

Themed Review

Living with Covid19 - webinars

The NIHR Centre for Engagement and Dissemination has recently published the 'Living with Covid19' review compiling the current state of knowledge on ongoing Covid19 symptoms. Our review is seeking to frame a dialogue with the public, health and social care professionals, researchers, service providers and policy makers to better understand the issues around living with ...

Alert

INCLUDE Roadmap can help researchers make trials more inclusive

Many groups – such as women, older people and ethnic minorities – are under-served in clinical trials. An NIHR project aims to ensure that health research includes the people who most need it. The project is called Innovations in Clinical Trial Design and Delivery for the Under-served (INCLUDE); the current research formed the first phase ...

Alert

Artificial intelligence can predict the development of a leading cause of blindness

Artificial intelligence (AI) predicted the development of a leading cause of blindness in new research. A collaboration between Moorfields Eye Hospital in London and Google’s DeepMind and Google Health found that AI predicted the development of wet age-related macular degeneration (wet-AMD) more accurately than clinicians. Wet-AMD can lead to rapid and severe loss of sight. ...

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