Evidence
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Various drugs are effective and well-tolerated for generalised anxiety disorder

There are various drugs options for the treatment of generalised anxiety disorder, from different medication classes. This study found that most evidence was available for the serotonin and noradrenaline re-uptake inhibitors (SNRI) duloxetine and venlafaxine, the selective serotonin reuptake inhibitor (SSRI) escitalopram, and the anti-epileptic pregabalin. All appear well-tolerated and reduce symptoms compared with placebo. ...

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C-reactive protein is not useful in diagnosing late-onset infection in newborns

The blood level of C-reactive protein (CRP), a marker indicating inflammation in the body, is not accurate enough alone to diagnose late-onset infection in newborn infants. Late-onset neonatal infection, occurring more than three days after birth, is potentially serious and is relatively common. Tests measuring the blood level of CRP are widely used by physicians ...

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Long-term exercise programmes reduce falls and injuries in older adults

Older people who participate in year-long exercise programmes fall less and are less likely to be injured if they do fall. Exercise does not increase or decrease their risk of hospitalisation. The people aged 60 or over (average age 73 years) who were included in this review took part in supervised training programmes. Typically, about ...

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Torn Achilles tendons have similar outcomes if treated with or without surgery

Outcomes for ruptured Achilles tendons appear similar irrespective of the choice of intervention. This systematic review and meta-analysis found that while the risk of re-rupture with corrective surgery was small at 2.3%, with conservative management (immobilisation in a cast), the rate was only 3.9%. The complication rate at 4.9% was three times higher in those ...

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Management of Labour

Labour has three stages: The first stage is when the neck of the womb opens to 10cm dilated. The second stage is when the baby moves down through the vagina and is born. The third stage is when the placenta (afterbirth) is delivered. Labour and birth are intense and personal experiences.  Pregnancy can be a time of great anticipation and excitement but parents-to-be ...

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Brain scan may predict long-term disabilities in babies with brain injury

Magnetic resonance spectroscopy, a type of scan which shows brain biochemistry, could help predict whether there will be long-term effects of brain injury (encephalopathy) in new-born babies. It is usually done alongside an MRI. Researchers scanned 82 babies being treated for brain injury, using MRI and also magnetic resonance spectroscopy. One biomarker tested at seven ...

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Cognitive behavioural therapy may help ease depression in the workplace

Workplace-based interventions for people with depressive symptoms are effective. This review of 16 trials looked at early stage interventions to prevent depressive symptoms from developing into more severe depressive illness. Both cognitive behavioural therapy and some non-cognitive behavioural therapy interventions, such as supervised exercise, worked equally well. Telephone and internet-based therapy worked better than face-to-face ...

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Antimicrobial stewardship programmes reduce antibiotic use in long-term care homes

Antimicrobial stewardship programmes have been found to reduce antibiotic use in long-term care residences by 14% when pooling evidence across a range of study types and interventions. Antimicrobial resistance is a public health threat, and overuse of antimicrobials is one of the main causes. Antimicrobial stewardship programmes are a government strategy to support the appropriate ...

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An ultrasound scan is not as useful as a CT scan in assessing trauma

Ultrasound scans can be a useful tool to help pinpoint internal bleeding or organ damage in the chest or abdomen, but a negative scan cannot rule out damage, especially in children. Many emergency departments use portable ultrasound scanners to assess for internal damage when someone has been subject to blunt trauma (for example, involved in ...

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Medication to reduce stomach acid may increase risk of hip fractures

People who take proton pump inhibitors for digestive disorders such as stomach ulcers and acid reflux may be up to 24% more likely to experience hip fractures. Nevertheless, the benefits of treatment in an individual may outweigh this effect unless the risk of osteoporosis or fracture is high. A conversation between the prescriber and the ...

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