Evidence
Alert

Specialist nurses can manage heart failure drug dosing successfully

Use of specialist nurses to optimise drug dosages using protocols in people with heart failure was more effective than dose monitoring by other health professionals. These nurses had advanced practice certification. This finding came from a review of seven trials with more than 1600 patients. International guidelines recommend two or three first-line medications for people ...

Alert

Participation in health research may be linked to better care and performance

This NIHR review found positive evidence that engaging clinicians and healthcare organisations in research is linked to improvements in the delivery of healthcare. In the central part of this three-stage review, most (28/33) papers found a positive impact of research on quality or outcomes. Seven of these studies were able to show a relationship between ...

Alert

Weight loss surgery for obesity can lead to substantial weight loss and improved health outcomes

On average people lost 5 kg more in each of the first four months after weight loss surgery than those of a similar weight who did not undergo surgery. The risks of developing type 2 diabetes and high blood pressure were reduced. Surgery was linked to reduced risk of heart disease and sleep-related breathing problems. ...

Alert

Online cognitive behavioural therapy is no more effective than usual GP care for people with depression

Computerised cognitive behavioural therapy (CBT) in addition to usual GP care was no more effective than usual GP care alone at four months or at 24 months. It was also not a popular treatment for patients with mild to moderate depression who typically only used the programme once or twice. Indeed, more than four out ...

Alert

Improved tools to fairly compare the performance of critical care services

This NIHR-funded study refined the risk prediction models which are used to compare performance of critical care services and developed new risk prediction tools for heart attack sufferers in hospital. Critical care is highly specialised, intensive and costly, so audit of service performance is important for providers and commissioners. Risk prediction and audit are already ...

Alert

Continuous positive airway pressure treatment for obstructive sleep apnoea linked to fewer recurrences of heart rhythm abnormalities

Treating a common sleep-related breathing condition almost halved the chance of recurrent atrial fibrillation (AF, see Definitions). However, most of the included studies were observational. This makes it difficult to rule out the possibility of bias in choosing which patients to treat and therefore reduces our confidence in the size of this effect. The breathing ...

Alert

Routine replacement of intravenous cannulae is unnecessary and costly

Changing peripheral venous catheters ('cannulae') according to clinical need is just as safe as doing it routinely every three to four days. Bloodstream infections from either approach were rare, less than about one per 1000 insertions. This Cochrane review found that if the catheter is functioning and there are no signs of inflammation around the ...

Alert

Shared decision making in primary care can reduce antibiotic prescribing

Strategies, known as shared decision making, reduced antibiotic prescribing for people with acute respiratory infections by almost 40% in the short term (up to six weeks). This Cochrane systematic review compared the strategies that promote better discussions between doctor and patient about benefits and harms of treatment in primary care. Interventions were a mix of ...

Alert

Lower is better: blood pressure targets for high-risk people with diabetes or kidney disease

There were fewer heart attacks and strokes when people with cardiovascular conditions, diabetes or kidney disease followed lower blood pressure targets than usually recommended. This came at the expense of only a small increase in rates of severe low blood pressure. This updated systematic review and meta-analysis provided reliable evidence that more intensive blood pressure ...

Alert

Regular monthly and “as needed” injections for wet age-related macular degeneration are similar in effect

This review did not find evidence for a meaningful difference in outcomes between monthly and as-needed injections of vascular endothelial growth factor inhibitors (anti-VEGF) for wet age-related macular degeneration (AMD). Patients may prefer the treatment-as-needed approach, because it generally leads to fewer injections. After two years, people receiving injections as needed had 8.4 fewer injections ...

1041 Results 10 20 30 Results per page