A high sensitivity troponin test accurately ruled out a heart attack amongst a third of patients presenting to the emergency department with chest pain. A patient with no detectable troponin and normal electrocardiogram was almost certain not to have had a heart attack.
Many people come to hospital with chest pain, but more than 75% of them have not had a heart attack. The two tests accurately ruled out heart attack in 30% of all chest pain presentations, but more than a third of people who didn’t have a heart attack also tested positive. Only around a quarter of people with raised troponin have had a heart attack. The tests were less reliable in people who had chest pain for less than three hours.
The findings support existing NICE guidelines to use high sensitivity troponin testing in people with a suspected heart attack but without the classic features on an electrocardiogram. The test should not be used indiscriminately for all chest pain presentations.
Caution is needed due to the variability in individual study results, patient populations and testing protocols.
Why was this study needed?
Each year about 150,000 men and women in the UK suffer a heart attack, but over 700,000 attend hospital emergency departments with chest pain.
Patients with a heart attack usually have a blockage in one of the arteries supplying blood to the heart. They need urgent treatment to restore the blood supply to reduce permanent damage to the heart. Doctors need to quickly determine whether or not heart attack may be the cause of chest pain. Early rule-out may avoid unnecessary hospital admission, investigations and treatment.
Troponin protein is released from damaged heart muscle into the bloodstream. New high-sensitivity blood tests allow detection of a very low level of troponin soon after the onset of symptoms. The electrocardiogram (ECG) measures the heart’s electrical activity and can show abnormalities in a heart attack. This review aimed to see whether a negative high sensitivity troponin T assay and normal ECG can accurately rule out heart attack in the emergency department.
What did this study do?
This review identified 11 cohorts including 9,241 adults presenting to the emergency department with chest pain. All received an ECG and high sensitivity troponin T test.
Researchers looked at whether a troponin level of less than 0.005 µg/L (the lowest detectable level) when combined with normal ECG, was accurate in ruling out a heart attack. Heart attack was confirmed, independently in most studies, according to the Universal Global Task Force definition. Other outcomes were death or major adverse cardiac event (such as revascularisation) within 30 days.
Nine of the 11 studies had a high or unclear risk of bias. Individual studies varied in patient characteristics, timing and number of troponin tests, and their results. These factors may make meta-analysis inappropriate. All studies were from developed countries, but only one was from the UK.
What did it find?
- 30.6% of patients with chest pain were defined as low risk and tested negative, with a normal ECG and high sensitivity troponin below threshold (95% confidence interval [CI] 3.8% to 73.5%).
- These patients, testing negative, were almost certain not to have had a heart attack. The pooled negative predictive value was 99.3% (95% CI 97.3% to 99.8%).
- Only 14 patients (0.5%) had a ‘false negative’ result and were later confirmed to have had a heart attack. Seven of these were tested within three hours of the start of the pain. The pooled sensitivity was 98.7% (95% CI 96.6% to 99.5%) and was good across studies, ranging from 87.5% to 100%.
- The test wasn’t good for diagnosing a heart attack and gave a high number of incorrect ‘positive’ results in people without a heart attack. Pooled specificity was 64% (95% CI 49% to 77%). Specificity was low across studies but highly variable, ranging from 5% to 79%. Overall less than a quarter of people testing positive had a heart attack (positive predictive value 22%, 95% CI 19% to 27%).
- The test accurately identified almost all patients who died or had a major cardiac adverse event within 30 days (sensitivity 98.0%, 95% CI 94.7% to 99.3%). A total of 126 patients died (1.3% of the cohort), none of whom was in the low risk/test negative category.
What does current guidance say on this issue?
Current NICE guidance on chest pain (updated 2016) recommends that patients with a suspected heart attack should receive an ECG and high sensitivity troponin test on hospital arrival. If patients do not have the typical ECG features of a heart attack (ST elevation), a repeat high sensitivity troponin three hours later can confirm or rule out non-ST elevation heart attack.
Troponin measurement is not recommended for people presenting with chest pain who are not clinically suspected of having a heart attack.
What are the implications?
This meta-analysis generally supports NICE recommendations around the use of the high sensitivity troponin test in people with a suspected heart attack but without the classic ECG signs of ischaemia.
Although it is not reliable less than three hours after the onset of pain, where the ECG is normal the new high sensitivity assay may reduce waiting times and avoid unnecessary hospital admissions and associated costs.
Citation and Funding
Pickering JW, Than MP, Cullen L, et al. Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: a collaborative meta-analysis. Ann Intern Med. 2017;166(10):715-24.
This study was funded by the Emergency Care Foundation.
Goodacre S, Thokala P, Carroll C et al. Systematic review, meta-analysis and economic modelling of diagnostic strategies for suspected acute coronary syndrome. Health Technol Assess. 2013;17(1).
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NICE. Myocardial infarction (acute): early rule out using high-sensitivity troponin tests (Elecsys Troponin T high-sensitive, ARCHITECT STAT High Sensitive Troponin I and AccuTnl+3 assays. DG15. London: National Institute for Health and Care Excellence; 2014.
NICE. Chest pain of recent onset: assessment and diagnosis. CG95. London: National Institute for Health and Care Excellence; 2010.
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