Skip to content
View commentaries on this research

This is a plain English summary of an original research article

A comprehensive programme of daily telemedicine monitoring and 24-hour access to a physician-led hotline can reduce the number of deaths and the time spent in hospital, among patients with heart failure.

A year-long study of 1,571 patients who had been admitted to hospital with heart failure within the past 12 months found that those assigned to daily telemonitoring, monthly health education and telephone support from specialist staff, were 30% less likely to die than those assigned to usual care. This was a 3 percentage point reduction from 11% per year in the control group to 8% in the telemedicine group. This group also spent around a third fewer days in hospital.

This suggests telemedicine could make a real difference to patient outcomes for heart failure. The study was set in Germany and costs of the intervention may differ in the UK. So it would be useful to know how the programme compares to usual care in the UK before it is rolled out here.

Why was this study needed?

An estimated 900,000 people in the UK live with heart failure, often alongside other co-morbidities, and unplanned hospitalisation is common. The numbers of newly-diagnosed patients have been rising.

Previous studies of telemedicine with the aim of reducing hospital admissions have been inconclusive and have tended to focus on the technology itself. This study aimed to evaluate the effects of a comprehensive telemedicine programme on a carefully-chosen group of people with heart failure. They all had worsening heart failure in the past 12 months requiring hospital admission, heart failure class 2 or 3 and a left ejection fraction less than 45% (or treated with oral diuretics). It did not include people scheduled for a heart procedure or those with depression, a common co-morbidity with heart failure.

What did this study do?

The TIM-HF2 randomised controlled trial included 1,571 people from 200 hospitals throughout Germany. Telemedicine was compared with usual care.

The 765 patients assigned to telemedicine care were provided with equipment to monitor daily body weight, blood pressure, heart rate, heart rhythm, peripheral capillary blood oxygen saturation and self-rated health status. A telemedicine centre reviewed patient data and could make adjustments to care or arrange for a patient to be seen or admitted if necessary.

Nurses also provided health education every month by telephone and patients had 24-hour emergency access to a doctor-led helpline. Outcomes were compared with 766 patients who received usual care over 12 months.

Patients in the telemedicine group were trained to use the equipment and may have been more motivated to take control of their heart failure than most.

What did it find?

  • There were fewer deaths in the telemedicine group: 8% in a year compared with 11% per year in the usual care group. This represented a 30% reduction in all-cause mortality (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.50 to 0.96).
  • Patients in the telemedicine group spent on average 3.8 days a year in hospital for unplanned admissions, compared with 5.6 days for the usual care group.
  • The primary outcome was a combination of days lost to either unplanned hospital admission or death from any cause. An average 17.8 days (95% confidence interval (CI) 16.6 to 19.1) were lost among the telemedicine group and 24.2 days (95% CI 22.6 to 26.0) were lost among the usual care group.
  • Although cardiovascular mortality was lower among the telemedicine group (5% compared to 8%), this did not meet statistical significance (HR 0.67, 95% CI 0.45 to 1.01).

What does current guidance say on this issue?

The 2018 NICE guideline on chronic heart failure in adults recommends people receive sufficient education and support if they wish to be involved in monitoring their condition. They should also be advised on what to do if their condition deteriorates. However, the use of telemedicine is not addressed.

The European Society for Cardiology’s 2016 guideline on diagnosis and treatment of heart failure states that management programmes for patients with heart failure after discharge from hospital should include regular clinic and/or home-based visits and possibly telephone support or remote monitoring.

What are the implications?

The study suggests that heart failure management through a comprehensive telemedicine package could improve mortality, although the potential costs of this in Germany are not reported. The intervention also appeared to reduce hospital stays. Lack of detail in the ‘usual care’ group means we cannot be sure how the study might translate to the UK. The intervention provides input from physicians and specialist nurses responding to patients and is likely to be high cost.

However, the results are persuasive and suggest that elements of telecare could be tested in UK heart failure treatment programmes. The cost and cost-effectiveness of a UK programme could also be evaluated. This is an area of interest for commissioners, general practitioners, community nurses and cardiology teams, as well as people with heart failure and their families, given the impact on quality of life and daily functioning.

Citation and Funding

Koehler F, Koehler K, Deckwart O et al. Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial. Lancet. 2018;392:1047-57.

The study was funded by a research grant from the German Federal Ministry of Education and Research.



Inglis  SC, Clark  RA, Dierckx  R et al. Structured telephone support or non‐invasive telemonitoring for patients with heart failure. Cochrane Database Syst Rev. 2015;10:CD007228.

NHS website. Heart failure. London: Department of Health and Social Care; 2018.

NICE. Chronic heart failure in adults: diagnosis and management. NG106. London: National Institute for Health and Care Excellence; 2018.

Ponikowski P, Voors AA, Anker SD et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). European Heart Journal. 2016;37(27):2129–200.

Produced by the University of Southampton and Bazian on behalf of NIHR through the NIHR Dissemination Centre


  • Share via:
  • Print article


Heart failure classes describe how severe symptoms are, with class 1 being least severe and class 4 most severe:Class 1 – no symptoms during normal physical activityClass 2 – comfortable at rest, but normal physical activity triggers symptomsClass 3 – comfortable at rest, but minor physical activity triggers symptomsClass 4 – unable to carry out any physical activity without discomfort and may have symptoms even when resting 
Back to top