A simple, low-cost blood test offers great potential as a tool for diagnosing womb cancer, and for screening high-risk women. The test gives almost instant results and in a new study, it picked up changes in the womb that could lead to cancer (pre-cancerous growths).
In the UK, womb cancer is the fourth most common cancer in women. Survival is improving but it remains the eighth most common cause of cancer death in UK women. Current diagnostic procedures are expensive, invasive, or lack accuracy.
This study investigated a technique involving infrared light to determine the ‘molecular fingerprint’ of blood samples, to find out whether it could be useful for detecting womb cancer. The researchers looked for key differences in samples from women that could confirm whether they had womb cancer or precancerous growths that might develop into the disease.
Across all stages of womb cancer, the test detected disease with a high degree of accuracy, especially in early-stage disease. The study confirms that an innovative, non-invasive technique could help to identify womb cancer early.
What’s the issue?
Around 9,500 women are diagnosed with womb cancer in the UK every year. Since the early 1990s, numbers have increased by 55%, mainly because of an increase in obesity.
Early detection increases the chances that the disease can be treated successfully and may allow management that spares fertility. In 2016, the NHS set out the ambitious target that diagnosis should be established within 28 days of attending primary care.
Most women with womb cancer have abnormal vaginal bleeding, which prompts their referral for further investigations. Diagnosis currently involves a transvaginal ultrasound scan, followed by a biopsy which may require a general anaesthetic. The process is invasive, expensive and lacks accuracy. In some cases, the disease may have reached an advanced stage before it causes any signs or symptoms.
There is a need for simple, effective new tools to help detect womb cancer in women with or without symptoms of the disease.
The researchers analysed blood samples collected from 652 women: 342 women with womb cancer; 68 with precancerous growths in their womb lining; and 242 healthy women. They adjusted the data for patient characteristics including age, obesity, and diabetes, which are linked with an increased risk of womb cancer.
A screening test needs to have high sensitivity and be very likely to detect the disease when it is present. It also needs to have high specificity so that it does not suggest cancer by mistake in healthy women. This causes unnecessary distress and leads to unnecessary investigations.
Overall, this study showed that the new technique has the potential to detect womb cancer with:
- 87% sensitivity – it could pick out womb cancer in 87 out of 100 samples from women who had the disease
- 78% specificity – it incorrectly suggested cancer in 22 out of 100 samples from healthy women.
The results were better for detecting type 1 cancer, the most common subtype:
- 91% sensitivity
- 81% specificity.
The test was most accurate for detecting the precancerous growths in the womb that can lead to cancer. It had:
- 100% sensitivity
- 88% specificity.
Why is this important?
This is the largest study to date exploring the potential of this technique as an early detection tool for womb cancer. The results demonstrate that a simple, low-cost blood test can accurately detect womb cancer, as well as precancerous growths that could develop into the disease.
The necessary equipment is portable and gives an immediate result. It could be used within primary care settings as a bedside diagnostic tool. In clinical settings, this test could help ensure that invasive or expensive follow-up procedures are offered only to women at high risk of developing the disease. This would reduce pressure on cancer diagnostic services.
The test also has potential as a screening tool to help identify women with precancerous growths that could later develop into womb cancer – helping to prevent the disease early and spare their fertility.
Even larger studies are now needed to confirm the results in the general population and in high-risk groups. These include women with obesity or certain genetic conditions that can increase the risk of the disease.
Future clinical trials following healthy women at high-risk of womb cancer for many years will be needed. They will establish whether this approach offers benefits over current diagnostic procedures for the early detection of womb cancer.
You may be interested to read
The full paper: Paraskevaidi M, and others. Detecting Endometrial Cancer by Blood Spectroscopy: A Diagnostic Cross-Sectional Study. Cancers. 2020;12:1256
Gajjar K, and others. Fourier-transform infrared spectroscopy coupled with a classiﬁcation machine for the analysis of blood plasmaor serum: a novel diagnostic approach for ovariancancer. Analyst. 2013;138:3917-3926
Cancer Research UK. Patient information about womb cancer. 2020
Funding: This study was supported by the Rosemere Cancer Foundation and the NIHR Manchester Biomedical Research Centre. It was partly funded by NIHR Clinical Scientist Fellowships and an Academic Clinical Fellowship.
Conflicts of Interest: The study authors declare no conflicts of interest.
Disclaimer: NIHR Alerts are not a substitute for professional medical advice. They provide information about research which is funded or supported by the NIHR. Please note that views expressed in NIHR Alerts are those of the author(s) and reviewer(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.