Evidence
Alert

Loneliness, but not social isolation, predicts development of dementia in older people

Older people who feel lonely and have few close relationships may have an increased chance of developing dementia. Perhaps surprisingly, being socially isolated with few or infrequent social contacts does not seem to predict dementia risk, researchers found. This study was carried out before the coronavirus pandemic but the findings are relevant now, when the …

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Cancer screening across the world is failing people with mental illness

People with mental illness are nearly 25% less likely to receive cancer screening than those in the general population. Results from a large international study suggest this is one explanation for why people with mental illness tend to die 15-20 years earlier than other people. The study included more than 4.5 million people across the …

Collection

My Signals – Depression

In Collections, health and social care staff and service users tell us what research is important to them and why they feel others need to know about it. In this collection, we asked nine mental health practitioners and members of the public to tell us which Alerts have interested them most. Michelle Edgar A former …

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Increasing omega-3 intake does not prevent depression or anxiety

Increasing intake of polyunsaturated fats, for example with omega-3 fatty acid supplements, has little or no effect in preventing the onset of depression or anxiety symptoms in people without these conditions, but who might be at risk. These findings support dietary advice that omega-3 supplements are not needed in healthy people. This review also highlights …

Collection

My Signals – Patients, 2019

In My Signals, health and social care staff and service users tell us what research is important to them and why they feel others need to know about it. In this collection, we asked seven members of the public to tell us which Signals have interested them most and explain why they feel the findings …

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Voucher rewards do not reduce frequency of cannabis use or relapse in people with early psychosis

Contingency management – the use of positive reinforcement in the form of supermarket vouchers to shape behaviour – makes no difference in the frequency of cannabis use or relapse rates in those with early psychosis. Although psychotic symptoms initially decrease, these changes are not sustained over the longer term and are no better than with …

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A nurse-led intervention did not reduce post-traumatic stress disorder symptoms in critical care patients

For adults in critical care, a complex psychological intervention delivered by nurses did not reduce the severity of post-traumatic stress disorder (PTSD) symptoms at six months, compared with usual care. The intervention included creating a therapeutic environment, three stress support sessions, and a relaxation/recovery programme. A cost-effectiveness evaluation showed great uncertainty over whether the programme …

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Combined drug therapy for at least 36 weeks reduces relapse after psychotic depression

Patients with psychotic depression who achieve remission benefit from continuing the antipsychotic drug olanzapine, alongside the antidepressant sertraline for at least a further four months, a North American trial has found. Patients who reduced and stopped olanzapine when their condition stabilised were more than twice as likely to relapse when compared with those who continued …

Collection

My Signals – Occupational Therapy

In My Signals, health and social care staff and service users tell us what research is important to them and why they feel others need to know about it. In this collection, we asked seven occupational therapists to tell us which Signals have interested them most and explain why they feel the findings are worth …

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‘Last resort’ antipsychotic remains the gold standard for treatment-resistant schizophrenia

Among patients with schizophrenia that has not responded to other drugs, the antipsychotic drug clozapine cuts the chances of hospital admissions and drug discontinuation. Recent trials have questioned the superior efficacy of clozapine compared with other standard antipsychotic drugs. However, a review of real-world data from observational studies confirms its place as a drug that may …

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