Evidence
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London 2012 Olympics regeneration had minimal impact on physical and mental health

The London 2012 Olympic and Paralympic Games had only small and transient effects on physical activity, mental health and well-being for those living nearby. Although access to sporting facilities and green space improved, local adolescents and their parents did not receive any sustained positive effect on physical activity, mental health or well-being. This NIHR-funded study assessed …

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Early cooling provides no benefit following traumatic brain injury

Deliberate cooling (prophylactic hypothermia) in the early management of traumatic brain injury does not improve neurological outcomes at six months. Inducing hypothermia may also increase the risk of pneumonia. Hypothermia (33-35oC) is sometimes induced to try and limit brain damage in people with severe head injuries. However, evidence for its safety and effectiveness has been …

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Antibiotics may be an alternative first-line treatment for uncomplicated appendicitis

Appendicectomy surgery could potentially be avoided for around 60% of adults with uncomplicated appendicitis if they receive antibiotics first. Adults in Finland with appendicitis were randomised to have appendicectomy or a course of antibiotics. In 6 out of 10 the appendicitis settled and did not return over the five years they were followed. Of those …

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Aerobic exercise is an effective treatment for depression

A systematic review shows aerobic exercise improves clinically diagnosed major depression compared with antidepressants or treatment as usual. Previous reviews found conflicting evidence of benefit. The new review only included the trials thought to have the most applicable results. This meant that trials recruiting people who might not have a clinical diagnosis of depression or …

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Premature babies have fewer complications if a lower platelet count is accepted

Fewer premature babies die or have major bleeding if platelet transfusions are withheld until platelet numbers drop to a lower level. At 28 days, death or new major bleeding occurred in 19% of neonates transfused when they had less than 25,000/mm3 platelets compared to 26% of neonates transfused when they had less than 50,000/mm3 platelets. …

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Reviewing inhaler technique for older people with COPD can improve disease control

Educating older adults with chronic obstructive pulmonary disease or asthma about the correct way to use their inhalers, as part of disease management, can reduce their risk of exacerbations. Either a demonstration using a placebo inhaler or written information appears effective for this. This review pooled the results of four trials, with a total of …

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Radiotherapy benefits some men whose prostate cancer has spread to their bones

Adding radiotherapy directed at the prostate to hormone treatment for all men with metastatic prostate cancer makes no difference to overall survival. However, when men with a limited number of metastases confined to the bones of the pelvis and spine are treated with radiotherapy to the prostate, their survival improves. The standard treatment for men …

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Lifestyle changes may be more important than drugs for mild hypertension

Consideration of wider risk factors may be important when treating adults with low-risk mild hypertension (raised blood pressure). A large NIHR-funded UK study compared rates of mortality and risk of cardiovascular disease between patients who received antihypertensive treatment and those who did not. There was an increased risk of adverse effects, like low blood pressure. …

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Combining mirtazapine with other antidepressants is not effective for treatment-resistant depression

Adding mirtazapine to first-line antidepressants for adults with treatment-resistant depression does not improve symptoms when compared with placebo (dummy pills). People taking mirtazapine are more likely to experience side effects, and stop taking their treatment. This NIHR-funded trial took place in 106 general practices in England, recruiting 480 adults with mild to severe depression. All …

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The benefits of commonly used blood pressure and cholesterol lowering treatment can last 16 years

Fewer deaths from stroke had occurred in people who had high blood pressure treated with amlodipine, a calcium-channel blocker, compared to atenolol, 10 years after the end of a large trial. People with high blood pressure who took statins were less likely to die from cardiovascular diseases, such as heart disease or stroke than those …

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