This NIHR-funded systematic review found that exercise referral schemes increased physical activity in people who have no or little physical activity to begin with compared with usual care or advice. But these schemes do not appear to be cost-effective for all people.
Exercise referral schemes may be more effective for people with coronary heart disease risk factors than for people with mental health conditions, for example. Most of the trials were based in the UK, making the findings directly relevant here.
Prior to publication, the findings of this review informed the 2014 update to the NICE public health guideline on exercise referral schemes. The updated guideline recommends exercise referral schemes only for people who have existing health conditions or other health risk factors and are sedentary or inactive.
Why was this study needed?
Over the last two decades, exercise referral schemes have been adopted by the majority of primary care organisations in the UK. Usually primary care practitioners will refer to local authority leisure facilities for the delivery of an exercise programme. These can use indoor, community or outdoor settings for a variety of activities, like walking, swimming or gym classes. The majority of schemes offer between three to seven different activities as options and the typical length of the referral period in England and Scotland is 12 weeks. In 2006, the NICE public health guideline on four commonly used methods to increase physical activity concluded that there was insufficient evidence to recommend using exercise referral schemes. A 2011 NIHR-funded systematic review found no trial-based evidence of the effectiveness of exercise referral schemes in people with existing medical conditions. For people without a medical condition the 2011 review reported considerable uncertainty about the effectiveness and cost-effectiveness of exercise referral schemes for increasing levels of activity and improving health risk factors.
This NIHR-funded systematic review and economic evaluation aimed to update the 2011 review to find out if there was recent evidence to support the use of exercise referral schemes to promote physical activity. Prior to publication, this update provided the evidence base for updating the NICE guideline on exercise referral schemes in 2014.
What did this study do?
This systematic review searched several medical databases for trials comparing exercise referral schemes with a control group who received usual care or advice. The 2011 review results found seven trials and this update review found one more - an evaluation study incorporating a randomised controlled trial and qualitative evidence. The new trial, published in 2012, was the largest so far with over 2,000 people randomised in the UK. Uptake of exercise referral was high (at 85%) amongst those allocated to the intervention. As the trial was so large, it was important to update the evidence. Four trials included people with high risk factors for medical conditions and four included people with sedentary lifestyles, giving a total of 5,190 participants. Six of these studies were conducted in the UK and all trials were rated as moderate to high quality. The overall impact of the exercise referral schemes was pooled in a meta-analysis. The qualitative evidence was summarised in a narrative review.
This review included an economic evaluation to establish the cost-effectiveness of exercise referral schemes.
What did it find?
- People on different exercise referral schemes were 12% more likely to achieve 90 to 150 minutes of at least moderate level of exercise per week compared with usual care at 6 to 12 months (relative risk [RR] 1.12, 95% confidence interval [CI] 1.04 to 1.20).
- On average, different exercise referral schemes increased the number of minutes per week of physical exercise by 55.10 minutes compared with the control groups who received advice only (95% CI 18.47 to 91.73 minutes).
- Exercise referral schemes compared with usual care did not increase physical activity for people with mental health conditions but did for people with coronary heart disease risk factors (odds ratio [OR] 1.29, 95% CI 1.04 to 1.60).
- Enrolment (initial attendance) in exercise programs was mixed, ranging from 35% to 100% in the eight trials. Continuous participation (finishing the course) varied from 21.5% to 86%. The qualitative evidence suggested that the main barriers for engaging with the exercise referral scheme included lack of car ownership, living in a rural area or deprivation.
- Exercise referral schemes overall were estimated to cost an additional £76,000 for each added Quality Adjusted Life Year (QALY) compared to usual care. This is a measure of the value for money offered by a medical intervention. This is more than double the usual £20,000 to £30,000 guide used by NICE to assess whether something is a cost effective use of NHS resources.
What does current guidance say on this issue?
The 2014 NICE public health guideline on exercise referral schemes to promote physical activity recommends that primary care practitioners should not refer healthy people who are sedentary or inactive to exercise referral schemes. This guideline recommends that only people who have existing health conditions or other health risk factors and are sedentary or inactive should be referred to exercise schemes.
Structured exercise programmes for management or rehabilitation after recovery from specific medical conditions are not part of the exercise referral schemes.
What are the implications?
Physical activity is known to be of near universal benefit. It can reduce your risk of major illnesses, such as heart disease, stroke, type 2 diabetes and cancer and lower your risk of early death by up to 30%. This review asked if referring people for exercise programmes can help them to realise these benefits. Most of the trials in this systematic review were conducted in the UK which makes its findings highly relevant to the UK context. The details of exercise referral schemes varied across studies and the analysis could not identify which elements promoted changes to physical activity levels. Exercise referral schemes can be more or less successful for people with different medical conditions or risk factors. They may also have an impact on more than one risk factor or condition, so this should be taken into consideration when implementing these programmes. The cost effectiveness estimates of the exercise interventions depend on multiple assumptions, such as the length and cost of exercise referral schemes and the amount of health benefit gained, meaning that any estimate is uncertain. In the analysis a small increase in quality of life was gained at an additional cost of £225 per person.
NICE public health advisory committee considered the cost effectiveness evidence and even in the best case scenario, the estimated incremental cost effectiveness ratio was £31,009 per QALY gained. Despite this, experts noted that some specific schemes may be cost effective, or may only be cost effective for the subgroups for which the recommendation applied. They concluded that cheaper schemes, costing less than £150 per person, might be cost-effective at a threshold of £20,000–£30,000 per QALY if they remained effective. They also noted that if exercise referral schemes collected more detailed data, this would allow commissioners to make a more informed decision on future investment.
Campbell F, Holmes M, Everson-Hock E, et al. A systematic review and economic evaluation of exercise referral schemes in primary care: a short report. Health Technol Assess. 2015;19(60):1-110.
This project was funded by the National Institute for Health Research Health Technology Assessment programme (Project number 13/45/01).
Anokye NK, Trueman P, Green C, et al. The cost-effectiveness of exercise referral schemes. BMC Public Health. 2011;11:954.
NICE. Exercise referral schemes to promote physical activity. PH54. London: National Institute for Health and Care Excellence; 2014.
NICE. Four commonly used methods to increase physical activity. PH2. London: National Institute for Health and Care Excellence; 2006.
NICE. Walking and cycling. PH41. London: National Institute for Health and Care Excellence; 2012.
NICE. Physical activity: brief advice for adults in primary care. PH44. London: National Institute for Health and Care Excellence; 2013.
Pavey TG, Anokye N, Taylor AH, et al. The clinical effectiveness and cost-effectiveness of exercise referral schemes: a systematic review and economic evaluation. Health Technol Assess. 2011;15(44):i-xii, 1-254.
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