Evidence
Alert

New drugs for deep vein thrombosis may offer a safe alternative to warfarin

This Cochrane systematic review found that two new types of drugs taken by mouth for deep vein thrombosis were as effective as standard treatment, which most commonly involves treatment by injection followed by warfarin tablets for at least three months. The new drugs have the advantage that they do not require monitoring or dose changes …

Alert

Self-management support for stroke survivors may improve independence

This NIHR-funded summary of systematic reviews looked at the evidence on self-management support for stroke survivors. It found that the term self-management was rarely used in the literature. There was high quality evidence that therapy-based rehabilitation, some of it including components supporting self-management, had a beneficial effect on the basic activities of daily living, such …

Alert

Exercise referral schemes increase physical activity for some

This NIHR-funded systematic review found that exercise referral schemes increased physical activity in people who have no or little physical activity to begin with compared with usual care or advice. But these schemes do not appear to be cost-effective for all people. Exercise referral schemes may be more effective for people with coronary heart disease …

Alert

Talking therapies may prevent relapse of depression

This review looked at how effective different psychological “talking” therapies were at preventing relapse of depression. It found that cognitive behavioural therapy, mindfulness-based cognitive therapy and interpersonal psychotherapy all reduced the risk of depression relapse over a year by 20 to 25% compared with a control treatment. There was further evidence that the effect for cognitive …

Alert

Education and support groups help carers of people with severe mental illness

This systematic review found that carer-focused interventions can improve the experience of caring, carer quality of life and reduce psychological distress in those caring for people with severe mental illness in the community. Psychoeducationand support group style interventions delivered by health and social care services led to improvements in carer outcomes such as how positively …

Alert

Continuous positive airway pressure led to less daytime sleepiness in older adults with sleep apnoea

This NIHR trial found that continuous positive airway pressure for obstructive sleep apnoea in people aged 65 and over led to less daytime sleepiness and was reasonable value for money. Obstructive sleep apnoea causes the airway to close intermittently overnight leading to daytime sleepiness. It is most common in older people, but previous studies have …

Alert

Treatment of mother-child interaction might be of value for childhood anxiety disorder

Child cognitive behavioural therapy helps children with anxiety disorders. But children of mothers with anxiety disorder are less likely to improve. This trial (MaCH) found that treating maternal anxiety disorder at the same time as the child’s provided no additional treatment benefit. The treatments tested were maternal cognitive behavioural therapy or a new treatment focused …

Alert

Pre-hospital non-invasive ventilation for people with acute respiratory failure

This NIHR-funded systematic review and cost-effectiveness study found that pre-hospital (i.e. in the ambulance) non-invasive ventilation in the form of continuous positive airway pressure for people with acute respiratory failure, can reduce both the risk of dying and the need for ventilation in intensive care. The small device used by trained ambulance personnel was more …

Alert

Whooping cough infection common in school aged children with stubborn coughs

This NIHR-funded study found that almost a fifth of children aged five to 15 years who visited their GP with persistent cough showed signs of recent whooping cough infection, despite having a booster vaccination before school age. These data, from 22 GP practices in Thames Valley UK, describe the duration of vaccine-induced immunity and the …

Alert

Two drug treatments for severe alcoholic hepatitis do not improve survival rates

This NIHR funded trial found that neither prednisolone nor pentoxifylline improved mortality for people with severe alcoholic hepatitis. No differences were found in mortality at 28 or 90 days, or in the need for liver transplant at one year. Overall mortality was high. Nearly three in ten people died before 90 days and more than …

713 Results 10 20 30 Results per page