Evidence
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One group of drugs used to treat Crohn’s disease is unlikely to prevent relapse

Anti-inflammatory drugs called 5-aminosalicylic acids (5-ASAs) do not prevent relapses of Crohn’s disease when compared to placebo at one year. Crohn’s disease is a long-term inflammatory condition which can affect any part of the gastrointestinal tract, causing pain, diarrhoea and weight loss. It is characterised by recurring bouts of inflammation which can be severe. Once ...

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Low-dose sedative reduces sudden confusion after major surgery in older adults

Giving a low-dose sedative to older adults in intensive care after surgery reduces sudden confusion, also known as delirium, without increasing the risk of adverse effects. In this Chinese trial, adults aged 65 or over were given an intravenous drip of the sedative dexmedetomidine on their first day in intensive care following non-heart surgery. Nine ...

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Long-haul flyers could reduce risk of leg blood clots with compression stockings

Airline passengers could reduce their risk of getting a deep vein thrombosis by wearing compression stockings, even if they are at low risk. Deep vein thrombosis (DVT) is a clot in the deep leg veins, and immobility is a risk factor. The chance of air travel causing DVT in healthy people is low, and many ...

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People prefer shorter compression stockings to prevent blood clots

People having surgery prefer wearing knee length to thigh length compression stockings to prevent deep vein thrombosis (DVT). They are more likely to wear knee length stockings correctly and for the recommended time. DVT is a clot in the deep leg veins and surgery is a known risk factor. If the clot travels to the ...

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Nitrofurantoin is as effective as other long-term antibiotics for preventing recurrent urinary tract infections

The antibiotic nitrofurantoin works as well as other long-term antibiotics for preventing recurrent urinary tract infections in women. However gastrointestinal side effects were more common in people on nitrofurantoin. The potential for inducing less antibiotic resistance compared to trimethoprim is a potential advantage of nitrofurantoin but this wasn’t a specified outcome for this review. This ...

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Surgical clot removal within seven hours of stroke improves function

For ischaemic stroke caused by a blood clot, early surgical clot removal alongside medical treatment improves functional outcomes at three months compared with medical treatment alone. Urgent stroke treatment is known to improve outcomes. Endovascular thrombectomy is a relatively new technique to mechanically remove the clot, where this is possible. Uncertainty over the optimal timing ...

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The heart failure drug levosimendan doesn’t improve outcomes in adults with severe infections

Septic shock is a life-threatening condition resulting from serious infection. Adding levosimendan to the usual care of adults with septic shock did not reduce the risk of death up to 28 days, nor the degree of damage to essential body organs. It probably also increased patients’ risk of abnormally fast heart rate and increased the ...

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Young people often have negative views of sex and relationship education

Sex and relationship education in schools is intended to safeguard children from harmful relationships and promote sexual health. This review of 55 qualitative studies, mainly from the UK, suggests the classes do neither and may be failing to prepare, protect or engage young people. Most studies covered secondary school sex and relationship education for pupils ...

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Supplementary feeding of preterm babies by cup rather than bottle helps breastfeeding success

For women who chose to breastfeed their preterm baby, supplementary feeds with a cup, compared with a bottle, led to improved breastfeeding rates at discharge and up to six months later. Preterm babies who are transitioning from being tube fed to breastfeeds have traditionally been given bottle feeds (of breast milk or formula) to supplement ...

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Extended hours in primary care linked to reductions in minor A&E attendances

Practices which offered additional appointments showed a reduction in the number of their patients attending emergency departments (also known as A&E) for minor conditions. There was no overall reduction in emergency visits. Costs were reduced for emergency departments but by less than the cost of the additional appointments. The study did not evaluate whether or ...

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