Evidence
Alert

Aspirin did not prevent deaths or disability in healthy older adults

In the ASPREE trial, older adults with no apparent cardiovascular disease who took daily aspirin saw no benefit in terms of reducing the chance of dying or having dementia or disability. Instead, it slightly increased their mortality and bleeding risk - aspirin was associated with an excess of 1.6 deaths per 1,000 people per year. ...

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Complications following hip or knee surgery are more likely for people with long-term illness, but benefits are still worthwhile

People with long-term illness are just as likely to benefit from knee or hip surgery as those without. However, they are more likely to have complications following surgery and to be readmitted within three months. This study reviewed data from 70 studies to determine the chance of short-term harms and long-term benefits linked to 11 ...

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Diet and exercise can reduce the risk of developing diabetes during pregnancy

Diet and exercise are effective ways of preventing the development of diabetes during pregnancy, known as gestational diabetes. Gestational diabetes is becoming more common and is associated with poorer outcomes for mother and baby. Diet, physical activity and weight are modifiable risk factors, but trials published to date have shown inconsistent results. This systematic review ...

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Benzodiazepines may increase length of stay and chance of delirium in intensive care

Benzodiazepines given during mechanical ventilation in intensive care could increase the risk of a longer hospital stay and delirium compared to other sedatives. A range of sedatives are used to reduce psychological distress in critically ill patients, but prior to this study, it was not clear which drugs are most effective. This systematic review looked ...

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A total diet replacement programme helped obese people lose weight and keep weight off

A programme of weekly behavioural support with total diet replacement led to over 7kg greater weight loss than usual care in primary care. This weight loss was maintained for a year after starting the 8-12 week low calorie programme. This trial, funded by NIHR and a commercial sponsor, was carried out in ten primary care ...

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Supervised exercise sessions increase physical activity and fitness of cancer survivors

Aerobic exercise and resistance sessions that include supervision help people living with cancer to meet guideline physical activity levels. Common behaviour change techniques that were shown to increase physical activity are goal setting, graded tasks (e.g. increasing exercise duration or intensity over time), and instruction on how to perform particular exercises. This review update looked ...

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Paracetamol and alcohol are the most common substances taken by young people and rates of poisoning are increasing

The rates of the five most common types of poisoning in young people have increased three to five-fold from 1998 to 2014 and is cause for concern. A study including more than 1.7 million young people aged 10 to 24 in the UK found records of 31,509 people who had been treated for poisoning (2% of the ...

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Ways of integrating care that better coordinate services may benefit patients

New integrated care models can increase patient satisfaction, perceived quality of care and improve access to services. It is less clear whether there may be effects on hospital admissions, appointments or healthcare costs. Strong leadership and patient engagement are among factors influencing successful implementation. The NHS is undergoing reconfiguration to better coordinate services around patients. ...

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Robot-assisted arm training after stroke helps people regain some strength and independence

People who have electromechanical or robot-assisted arm rehabilitation after stroke have better arm function and strength as well as finding it easier to complete activities of daily living. Although moderate, the improvements suggest it may be worth considering these interventions as an adjunct to usual therapy. Many people have impaired arm function after a stroke ...

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People with COPD exacerbations prefer early discharge then treatment at home

People with flare-ups of COPD (chronic obstructive pulmonary disease) prefer to be managed at home rather than in hospital. Hospital stay was on average four days shorter when people were discharged early to the hospital at home scheme, and there was no noticeable increase in readmissions in this group. This NIHR-funded trial aimed to establish ...

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