Evidence
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Guided online interventions can help people recover from depression

Internet-based interventions combined with remote professional support can improve outcomes for people with depression. Those receiving the intervention show better initial response to treatment and higher recovery rates compared with control groups who are either waiting for treatment or receiving less support. This meta-analysis shows people using guided internet therapy are over twice as likely ...

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Methylphenidate remains first-choice drug treatment for children and young people with ADHD

The stimulant methylphenidate has the best balance of effectiveness against side effects in children and young people with attention deficit hyperactivity disorder. Amphetamines are more effective, but also more likely to be stopped for a reason other than side effects. This large, NIHR-funded systematic review compared a range of drugs against each other through a ...

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Supporting families of those in intensive care improved family satisfaction but didn’t reduce family distress

A multicomponent support intervention for family members of patients in intensive care didn’t reduce their anxiety, depression or distress around the overall experience. However, it increased satisfaction with the quality of staff communication and delivery of care. Family members of critically unwell patients on intensive care often need to be involved in care decisions. Yet ...

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Tools for GPs can help reduce unnecessary antibiotic prescribing

Interventions to reduce inappropriate antibiotic prescribing for upper respiratory tract infections are most effective when they provide a negotiation tool to support patient interaction. These interventions are more likely to be rejected if they are perceived as interfering with individual clinical judgment or damaging patient relationships. Upper respiratory tract infections often resolve themselves within a ...

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Amphetamines probably the best first-choice treatment for adults with ADHD

There is further evidence to support the amphetamines as the most effective group of drugs for treating adults with attention deficit hyperactivity disorder in the short-term. Two of these drugs were shown to provide the most improvement in core symptoms of attention deficit hyperactivity disorder, are tolerated as well as any other drug treatment and ...

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Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes

Patients with type 2 diabetes who monitor their blood glucose themselves may see small, short-term improvements in blood sugar control. This is not enough to be clinically important or outweigh the costs and personal inconvenience of long-term self-testing. Self-monitoring is a well-established strategy for type 1 diabetes and for people with type 2 who need ...

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Albumin administrations can prolong survival for some people with liver disease

Weekly intravenous albumin can prolong the life for people with liver cirrhosis and uncomplicated ascites. Over about 18 months, 17% of patients given albumin died compared with 22% given standard care alone over 11 months. People with very severe (end-stage) cirrhosis develop various complications including a build-up of fluid in the abdomen (ascites). This is ...

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Closing five emergency departments not linked with increased hospital admissions, though ambulance call-outs increased

Closure of five small emergency departments in England was not associated with change in the number of hospital admissions, urgent care attendances or deaths among the local populations. However, ambulance call-outs increased by 14% relative to comparison areas, with a four-minute increase in the time to reach a hospital with an emergency department. Emergency departments ...

Collection

Nine ways research could save the NHS money

Nine ways research could save the NHS money In this highlight, we have carefully selected nine NIHR Signals that show how research could help to save the NHS money. This collection covers a range of treatments and initiatives that are cost effective for the NHS. You can find out more about Signals or read the latest on the Discover Portal. ...

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The blood-thinner apixaban is less likely to cause major bleeding than warfarin

People who take apixaban to prevent blood clots are less likely to suffer major bleeding complications than those taking warfarin. Findings are similar in different groups of people, such as those with irregular heart rhythm (atrial fibrillation) and those who have had joint replacement surgery. Warfarin has long been used as an anticoagulant but needs ...

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