Evidence
Alert

Laminar airflow in surgery might not reduce surgical site infections

The type of theatre ventilation system used during hip and knee replacement, abdominal or vascular surgery has no effect on the rate of surgical site infections. Prevention of surgical site infection is a complex area with many potential targets for action. So decisions relating to commissioning or decommissioning these systems will need to consider the ...

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Group therapy may help a few extra people quit smoking, if other methods fail

Smokers who receive six to eight sessions of a group behaviour treatment were almost twice as likely to quit as those using self-help programmes. However this represents only about four extra successes in every 100 who try. The quit rates after individual advice or brief support were very similar, but adding nicotine replacement gum and ...

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Infants anaesthetised without placing a tube in the trachea have fewer adverse breathing events

Adverse breathing events are about three times more common when using endotracheal tubes than laryngeal mask airways for infants under 12 months receiving non-urgent surgery. Airway problems are common during anaesthesia in children, accounting for three quarters of critical incidents and a third of cardiac arrests. They are more frequent in younger children, especially infants ...

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Chlorhexidine mouthwash is useful short-term for people with mild gum disease

In people with mild gum disease chlorhexidine mouthwash, in addition to tooth brushing, reduces plaque build-up in the first weeks or months of use. However, when used for longer than four weeks chlorhexidine mouthwash can lead to tooth staining and a build-up of chalky deposits on the teeth, called tartar. There is insufficient evidence to ...

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Financial incentives do not increase attendance for diabetic eye screening

Two types of financial incentives are not effective at increasing attendance at eye screening for people with diabetes who do not regularly attend screening. Surprisingly, financial incentives may even reduce the numbers of people attending screening. Retinopathy is a type of eye disease common to people with diabetes. Sight deteriorates only in the later stages ...

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Insulin pumps not much better than multiple injections for intensive control of type 1 diabetes

People with type 1 diabetes offered insulin pumps did not achieve better blood glucose control compared with those using multiple daily injections. Education remains important. While both groups saw improvements in blood glucose levels and fewer hypoglycaemic episodes (very low blood sugar) over two years, only one in four participants met NICE blood glucose targets. ...

Themed Review

Advancing Care - Research with care homes

There are more than twice as many people living in care homes in England and Wales, than there are people staying in hospital. Yet we know far more about effective treatments in hospital and less about what works most effectively to improve care for older people in care homes. Research in care homes is a ...

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Doxycycline may be a safer first option for treating a blistering skin condition

Doxycycline (an established antibiotic) may be a safer first option than the standard steroid treatment for people with the autoimmune skin condition bullous pemphigoid. The condition causes severe, itchy blistering. This NIHR-funded study showed that people started on doxycycline were 19% less likely to have severe, life-threatening or fatal events during the next 12 months ...

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An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock

A protocol called early goal-directed therapy (EGDT) begun in the emergency department, did not reduce mortality compared with usual care for people with septic shock. The six hour treatment protocol aims to restore circulation for people with septic shock based on treatments that progress in a structured sequence before admission to intensive care. The protocol ...

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Three psychological therapies are effective for adolescent depression

For adolescents with unipolar major depression, there was no difference in self-reported depressive symptoms or cost-effectiveness after 18 months for cognitive behavioural therapy (CBT), short-term psychoanalytic psychotherapy and brief psychological intervention. This was a large NIHR funded trial of three evidence-based psychological therapies often used in the NHS alongside medication or without it. Teenagers from ...

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