Evidence
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A supervised toothbrushing programme in nurseries reduced dental treatment costs

This cost analysis showed that a Scotland-wide programme of supervised toothbrushing in nurseries is linked to large savings in dental treatment costs because of the reduced levels of tooth decay in five year-old children. In the eighth year, the programme saved more than two and a half times the programme’s cost of implementation. The greatest ...

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New evidence available on corticosteroids added to antibiotics in severe pneumonia

For adults admitted to hospital with severe pneumonia, this review found that adding corticosteroids to the usual antibiotic treatment may be beneficial. The evidence was less supportive of using corticosteroids in people with less severe pneumonia. Results showed modest benefits in allowing patients to reach a clinically stable recovery and leave hospital an average of ...

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Rapid tests for diagnosing drug resistant tuberculosis are accurate and may be cost effective

This NIHR funded systematic review and economic evaluation found that three rapid tests for diagnosing drug resistant tuberculosis were highly accurate and likely to be cost effective in the UK. These tests produce results within one day of obtaining a sample. This is a significant reduction compared with the standard tests which can take about ...

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Electrical stimulation alongside other treatments may slightly improve ankle spasticity after stroke, but the clinical importance is uncertain

This systematic review and meta-analysis found that electrical stimulation produced a small, but statistically significant improvement, in tight muscles (spasticity) for people recovering from stroke. The clinical importance of the improvement is uncertain. For example, electrical stimulation improved joint flexibility by an average of 2.87 degrees and spasticity improved by 0.3 on a 5 point ...

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A new, simple postural manoeuvre can stop an abnormally fast heart rate

A simple postural change to the Valsalva manoeuvre (see Definitions) improves the effectiveness of this cheap, non-invasive means of treating supraventricular tachycardia - an abnormally fast heart rate over 100 beats per minute. The NIHR funded a pragmatic trial of the promising technique in ten hospital emergency departments in England. The trial found that laying ...

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A behavioural intervention for obese pregnant women did not reduce risk of diabetes

This large NIHR-funded UK trial found that a behavioural intervention for obese pregnant women did not reduce their risk of developing diabetes during pregnancy, or having a baby born too large for the duration of pregnancy (large-for-dates). However, the intervention did reduce the mothers’ weight gain slightly and increased their physical activity. Women received advice ...

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A coping programme moderately reduces depression and anxiety in carers of people with dementia

This NIHR-funded trial found that a programme to support carers of people with dementia was moderately effective in reducing carers’ depression and anxiety scores for up to two years. It was also cost-effective. The programme consisted of eight sessions delivered by psychology graduates, covering topics such as managing difficult behaviour, accessing support and planning for ...

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Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis

In this NIHR-funded trial babies with a viral chest infection (acute bronchiolitis) were treated either with a strong saline mist (nebulised 3% hypertonic sodium chloride) with standard care or standard care alone. The stronger than usual, hypertonic saline mist had no effect on the time it took for babies to be ready for discharge, nor ...

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Listening to music reduces pain and anxiety for patients having surgery

This systematic review found that music can moderately reduce pain and anxiety when played before, during or after surgery. It also strongly increased patient satisfaction. Music was equally effective whether chosen by the patient or not. It was most effective when played before surgery and when the patient was conscious, though it was still effective ...

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Clinics and activities in primary care can reduce heart disease deaths

This review found that primary care interventions at an organisational level for people with coronary heart disease reduced death rates for up to six years after the intervention, compared to usual care. The structured interventions lasted between one and three years and included activities like organising dedicated clinics to monitor and adjust medication to meet ...

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